ParkinsonCanadaV1, Main, Exploration, bibRecord, 003E71

Basal ganglia iron content in Parkinson's disease measured with magnetic resonance

Identifieur interne : 003E71 ( Main/Exploration ); précédent : 003E70; suivant : 003E72

Basal ganglia iron content in Parkinson's disease measured with magnetic resonance

Auteurs : Frank Q. Ye [Canada] ; Peter S. Allen [Canada] ; Peter S. Martin [Canada]

Source :

Movement Disorders [ 0885-3185 ] ; 1996-05.

RBID : ISTEX:E7076E7074FA20A81A26B59E2EFD2172EBB17F84

Descripteurs français

Pascal (Inist)
- Fer, Homme, Imagerie RMN, Noyau gris central, Parkinson maladie, Physiopathologie.
Wicri :
- topic : Fer, Homme.

English descriptors

KwdEn :
- Adult, Aged, Basal Ganglia (pathology), Basal ganglion, Female, Globus Pallidus (pathology), Human, Humans, Image Enhancement, Iron, Iron (analysis), Magnetic Resonance Imaging, Magnetic resonance imaging, Male, Middle Aged, Neurologic Examination, Nuclear magnetic resonance imaging, Parkinson Disease (diagnosis), Parkinson disease, Parkinson's disease, Pathophysiology, Putamen (pathology), Reference Values.
MESH :
- chemical , analysis : Iron.
- diagnosis : Parkinson Disease.
- pathology : Basal Ganglia, Globus Pallidus, Putamen.
- Adult, Aged, Female, Humans, Image Enhancement, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Reference Values.

Abstract

The possibility of using magnetic resonance (MR) to evaluate the severity of the pathological changes of Parkinson's disease (PD) is suggested by the known accumulation of iron in the basal ganglia in PD and the reduced signal evident from this area with conventional reduced signal evident from this area with conventional T2‐weighted MR imaging. To improve the specificity of MR for the measurement of tissue iron content, we have developed a method that quantifies the effects of paramagnetic centers sequestered inside cellular membranes, based on the echo time dependence of the decay of transverse magnetization caused by the local field inhomogeneities which are due to intracellular iron. This method enables an index of local tissue iron content to be calculated for structures of the basal ganglia. We report here the application of this method to a series of patients with PD (n = 12) and of normal, age‐matched controls (n = 13). Our objective was to determine whether this measurement of basal ganglia iron concentration correlates with the presence and severity of PD. We observed a significant increase in iron content in both the putamen and pallidum in PD as well as a correlation with the severity of clinical symptomatology. More severely affected patients had a higher iron content in both of these structures. Our results suggest that this MR measurement may provide a noninvasive method of measuring the severity of the pathological changes underlying PD.

Url:

https://api-v5.istex.fr/document/E7076E7074FA20A81A26B59E2EFD2172EBB17F84/fulltext/pdf

DOI: 10.1002/mds.870110305

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en">The possibility of using magnetic resonance (MR) to evaluate the severity of the pathological changes of Parkinson's disease (PD) is suggested by the known accumulation of iron in the basal ganglia in PD and the reduced signal evident from this area with conventional reduced signal evident from this area with conventional T2‐weighted MR imaging. To improve the specificity of MR for the measurement of tissue iron content, we have developed a method that quantifies the effects of paramagnetic centers sequestered inside cellular membranes, based on the echo time dependence of the decay of transverse magnetization caused by the local field inhomogeneities which are due to intracellular iron. This method enables an index of local tissue iron content to be calculated for structures of the basal ganglia. We report here the application of this method to a series of patients with PD (n = 12) and of normal, age‐matched controls (n = 13). Our objective was to determine whether this measurement of basal ganglia iron concentration correlates with the presence and severity of PD. We observed a significant increase in iron content in both the putamen and pallidum in PD as well as a correlation with the severity of clinical symptomatology. More severely affected patients had a higher iron content in both of these structures. Our results suggest that this MR measurement may provide a noninvasive method of measuring the severity of the pathological changes underlying PD.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Basal ganglia iron content in Parkinson's disease measured with magnetic resonance

Basal ganglia iron content in Parkinson's disease measured with magnetic resonance

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
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